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ADHD and Narcolepsy Comorbidity

ADHD Narcolepsy
ADHD

Modestino, E.J., & Winchester, J. (2013). A retrospective survey of childhood ADHD symptomatology among Adult Narcoleptics. Journal of Attention Disorders, 17(7), 574–582. https://doi.org/10.1177/1087054713480033 

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Medicine Lecture Series, Sleep Disorders Center, Department of Neurology, Boston University School of Medicine, Boston Medical Center, Boston, MA  Wednesday, January 15, 2014 

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Dr. Modestino's blogs about this

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Brain Reward Cascade

Modestino, E. J., Blum, K., Oscar-Berman, M., Gold, M. S., Duane, D. D., Sultan, S. G. S., & Auerbach, S. H. (2015). Reward deficiency syndrome: Attentional/arousal subtypes, limitations of current diagnostic nosology, and future research. Journal of Reward Deficiency Syndrome, 01(01). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545661/

This is our latest publication. It is a genetic study that accessed databases and employed 7,171,168 subjects. The results revealed a shared genetic relationship between ADHD and narcolepsy (Genes: FOXP2, RBFOX1, and GRIN2A). This study was groundbreaking not only because of its results, but also due to the technique used.

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Just published in July 2025!

Modestino EJ, Sharafshah A, Lewandrowski KU, Carey E, Mohankumar K, Thanos PK, et al. (2025) GWAS meta-meta-analysis and related analyses revealed a shared genetic background between ADHD and narcolepsy. Academia Molecular Biology and Genomics, 2. https://doi.org/10.20935/AcadMolBioGen7751

Podcast Link

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Editorial:

Modestino, E. J., Sharafshah, A., Lewandrowski, K.-U., Baron, D., Thanos, P. K., Lewandrowski, A. P. L., Badgaiyan, R. D., Dennen, C. A., & Blum, K. (2025). Narcolepsy: Like a rolling stone, a disorder without a neurobiological home...in need of answers. World Journal of Pharmaceutical Science and Research, 4(1), 44–47. https://doi.org/https://doi.org/10.5281/zenodo.14783720

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